Alberta Mirror

Tuesday, August 9, 2022

Women have a higher chance of knee wear and tear because of genetics

Alberta

Key takeaways: 

  • Women are twice as probably to develop knee osteoarthritis as males, earlier considered to be due to hormones.
  • A new analysis from the University of Alberta found genetic distinctions that result in more women being at danger for knee osteoarthritis than males. 

Knee wear and tear more in women: 

According to recent research at the University of Alberta, women have a more increased chance of knee osteoarthritis than men due to genetic distinctions, which paves the way for early detection and cure.

Adetola Adesida, the principal researcher for the research and a teacher of surgery, told Edmonton AM the variation was verified after testing bioengineered cartilage in simulated low gravity.

“Our research revealed that the way female cells respond to microgravity is more provocative, which could lead to more ache,” he said Friday.

His team saw that 15 genes associated with osteoarthritis were much more heightened in half of the female donors when reached to their male counterparts.

The finding backs earlier research showing females get knee osteoarthritis at double the pace of men, Adesida said. 

Read more: Alberta grants $10 million to Ukraine, including money for defensive military supplies

Knee wear and tear happen more to women than men

As genetics can be specified through blood, a straightforward blood test can identify if somebody is at a more increased chance for knee osteoarthritis and allow for early detection and treatment. 

Explore for cause

Adesida stated he chose to look into the case after discovering a lack of literature and data into the leading causes of knee osteoarthritis in women — until now, the main culprit was thought to be hormone distinctions. 

The research was performed using the cells of torn meniscus unable to be recovered and carried out by orthopedic surgeons. The cells from those menisci were then used to engineer more menisci to perform the experiments for both males and females. 

The simulations were held in a NASA-built bioreactor that delivered the outcomes. 

Source – cbc.ca

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